The Pikamee collab was wholesome, Pika is loved.
If we ignore personal reasons, and let's say Pika still want to stream, which she expressed she wanted to for a while making it the career she is serious about for the first time, I feel like this will just be a hiatus, Pikamee will return, she has many incentives to pursue full indie like kson (before vshojo, and also yes I know voms is already indie in technical terms, and pika gets the full cut of her income), I would say the chance of this would've been lower if she didn't meet kson, but having her as a friend and possibly learning how these things work, getting advices make this chance much higher.
There're obviously other career paths like being a corpo vtuber, but I feel like she'd lose some freedom and have to deal with corpo management (and other people), being limited with the type of content she might want to create, but gain the benefits of not having to deal with hiring her own manager, etc, and can focus on streaming.
Pika has grown a lot over the years and she's strong, so I have strong belief that she can have a similar career path as kson, and continue to strive with whatever decision she'll make, whether it's indie or a corpo vtuber. She's been doing this for 3 years afterall and people want change and improvements, which staying in VOMS might not be able to provide her with. (no 3d for example)