People do make different salaries in different regions. There is a reason why people in the Bay area are payed very well. That's because the talent pool is very high there and if you want some of that talent tool then you have to pay a good amount. But since there is a lot of them, they can fire them and still get more since there are others there. You also had the whole remote thing that was happening and because of how expensive the bay area is, they started to move to much cheaper places. What sucked is that some of those companies required for them to move back to the bay area.
You don't need to have your business in those places, since you can save money, but the issue would just be finding talent. But if you can find them then you would be saving money. I remember years ago that some indie/AAA devs were getting mad at some devs in China and other Asian countries because of how well there games were selling and how much they were making in general. "Well of course they are making a lot of money (profit), look at how little it cost for them to rent their office and pay their workers". So that's why they are succeeding but we are not. If this is an issue, before starting out try starting in some place that Is cheaper.
I heard about the doctor strike in South Korea. I don't know the full details, but it sounds like some doctors are pissed that they are not getting payed enough and are overworked. Instead of trying to improve conditions, the idea is for more doctors. Which would limit the chances of some of the current doctors being able to get raises. Not only that but medical schools would need to allow an additional 2k students each year. Those medical schools aren't designed to have that much of an increase in students. So potentially a drop in quality of education for some people.
In Japan last year, there was a strike (labor strikes are insanely rare from my understanding and have been non-existent in Japan for some time). There was a store that got bought out and they were going to fire a lot of there staff. The workers were pissed since that's that something that normally happens. They would have options or something in order to keep on working, but in the case of the store, a big portion of the workers were going to be let go without any other options. They have a labor union and the labor union was the one who organized the strike.
Just a few days ago Google laid off their YouTube Music Austin office. I'm not sure how, but Instagram comments are even way more of a cesspool than Twitter comments some how.